CAR-20/19-T Cells in Pediatric and Young Adult Patients With Relapsed/Refractory B Cell ALL (CAR-20/19-T)
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- STATUS
- Recruiting
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- End date
- Feb 1, 2024
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- participants needed
- 24
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- sponsor
- Medical College of Wisconsin
Summary
This is a phase 1, interventional, open label, treatment study designed to evaluate the safety and feasibility of infusion of CAR-20/19-T in pediatric and young adult subjects with B cell ALL that have relapsed after prior therapies or refractory disease and are not candidates for curative intent standard therapy. There will be two phases of this study. A dose escalation phase to determine the safe CAR-20/19-T cell dose in patients B-cell ALL. Once the desired dose has been identified there will be a 6-patient dose expansion phase at the specified dose level.
Details
| Condition | Acute Lymphoblastic Leukemia, in Relapse, Acute Lymphoblastic Leukemia With Failed Remission, Acute Lymphoblastic Leukemia Recurrent, Acute Lymphoblastic Leukemia Not Having Achieved Remission, Acute Lymphoblastic Leukemia, Pediatric, Acute Lymphoblastic Leukemia |
|---|---|
| Treatment | CAR-20/19-T cells |
| Clinical Study Identifier | NCT04049383 |
| Sponsor | Medical College of Wisconsin |
| Last Modified on | 22 April 2022 |
Eligibility
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