Ph 2 Maintenance Trial: Ixazomib vs Ixazomib-Lenalidomide for MM Patients

  • STATUS
    Recruiting
  • End date
    Feb 20, 2024
  • participants needed
    52
  • sponsor
    Oncotherapeutics
Updated on 26 January 2021

Summary

This is a randomized, Phase 2 study involving two arms evaluating the efficacy and safety of ixazomib alone and the combination of both ixazomib and lenalidomide as maintenance therapy for patients with multiple myeloma who have achieved at least partial response (PR) or better after receiving a bortezomib- and lenalidomide-containing combination front-line therapy.

Description

Patients who have achieved PR or better on a bortezomib- and lenalidomide-containing combination therapy will be randomized to receive maintenance therapy with 28-day cycles of either ixazomib alone or the combination of ixazomib and lenalidomide. If steroids were part of the patient's qualifying regimen, steroids will be administered using the same drug(s), schedule(s) and dose(s) as those of the last treatment cycle of the bortezomib-, lenalidomide- and steroid-containing regimen. Ixazomib will be administered per orem (PO) at 3 mg on days 1, 8 and 15 of 28-day cycles. Lenalidomide will be taken PO, once daily at the same dose as the last treatment on days 1 through 28 of the 28-day cycles. Patients will start the randomized maintenance therapy after receiving a minimum of 6 cycles of a bortezomib- and lenalidomide-containing combination treatment but may have received up to 8 cycles if they continued to show improvement in their response after the first 6 cycles. During cycle 1, patients will have clinical laboratory tests weekly (days 1, 8, 15 and 22) and MM disease assessments on day 22 to monitor for efficacy and potential toxicity. Beginning with cycle 2, patients will have clinical laboratory tests performed twice a month and MM disease assessments once a month. Patients will be treated until documentation of PD or if subject meets any of the treatment discontinuation criteria.

Details
Condition Newly Diagnosed Multiple Myeloma
Treatment Lenalidomide, Ixazomib
Clinical Study IdentifierNCT03733691
SponsorOncotherapeutics
Last Modified on26 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

\-
Each patient must meet all of the following inclusion criteria to be enrolled
in the study
Male or female patients 18 years or older
Patients must be receiving a frontline bortezomib- and lenalidomide-containing regimen for treatment of disease
Patients must meet the following clinical laboratory criteria
Absolute neutrophil count (ANC) grater or equal 1,000/mm3 and platelet count greater or equal 75,000/mm3. Platelet transfusions to help patients meet eligibility criteria are not allowed within 7 days prior to screening platelets or at investigator's discretion
Hemoglobin 8.0 g/dL. Use of erythropoietic stimulating factors and red blood cell (RBC) transfusions per institutional guidelines is allowed; however, most recent RBC transfusion must have been at least 7 days prior to obtaining screening hemoglobin or at investigator's discretion
Total bilirubin less or equal 1.5 times the upper limit of the normal range (ULN)
Calculated or measured creatinine clearance greater or equal 30 mL/min. Calculation is based on a standard Cockcroft and Gault formula (Section 14.2)
AST (SGOT) and ALT (SGPT) less or equal 3 x ULN or less or equal 5 x ULN if hepatic metastases are present
LVEF 40%. 2-D transthoracic echocardiogram (ECHO) is the preferred method of evaluation. Mitigated Acquisition Scan (MUGA) is acceptable if ECHO is not available
Patients must be transplant ineligible as determined by the treating physician
Patients must have a life-expectancy of more than 6 months
Patients must have a confirmed diagnosis of MM
Patients receiving front-line therapy must have achieved at least PR and have completed at least 6 cycles of treatment
The disease must have reached a plateau phase at the end of front-line treatment as demonstrated bythe same response (using IMWG criteria) in three consecutive tests with at least three weeks between each test
Patients must have received frontline treatment within 8 weeks of enrollment
Patient can adhere to the study visit schedule and other protocol requirements
Patient Eastern Cooperative Oncology Group (ECOG) performance status is 2
Patients must voluntarily give written consent before any study related procedure not part of standard medical care is performed, with the understanding that consent may be withdrawn by the patient at any time without prejudice to future medical care
Female patients must be postmenopausal for at least 1 year before screening visit OR surgically sterile. If patient is female of childbeating potential (FCBP), patient must agree to practice two effective methods of contraception, at the same time, from the time of signing the informed consent form through 90 days after the last dose of study drug. FCBP must also adhere to the guidelines of any treatment-specific pregnancy prevention program AND agree to practice true abstinence when this is in line with the preferred and usual lifestyle of the subject. Periodic abstinence (e.g. calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception
Male patients, even if surgically sterilized (i.e., status post-vasectomy), must agree to one of the following
To practice effective barrier contraception during the entire study treatment period and through 90 days after the last dose of study drug
To practice true abstinence when this is in line with the preferred and usual lifestyle of the subject. Periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception

Exclusion Criteria

Patients meeting any of the following exclusion criteria are not to be enrolled in the
study
Patient is currently progressing on a bortezomib- and lenalidomide-containing regimen
Patients who have received more than 1 line of therapy (thus non-frontline treated patients)
Patients who were exposed to ixazomib during frontline therapy
Patient has > Grade 3 peripheral neuropathy or Grade 2 with pain during the screening period
Patient has known gastrointestinal disease or gastrointestinal procedure that could interfere with the oral absorption or tolerance of ixazomib including difficulty swallowing
Female patients who are lactating or have a positive serum pregnancy test during the screening period
Major surgery within 14 days before enrollment or at investigator's discretion
Patients undergoing stem cell therapy (SCT) or those who are planned for SCT
Radiotherapy within 14 days before enrollment or investigator's discretion. If the involved field is small, 7 days or investigator's discretion will be considered a sufficient interval between treatment and administration of the study drugs. Receipt of localized radiation therapy does not preclude enrollment
Infection requiring systemic antibiotic therapy or other serious infection such as known active hepatitis B or C virus infection, known human immunodeficiency virus (HIV) positive within 14 days before of study enrollment or at investigator's discretion
Evidence of current uncontrolled cardiovascular conditions, including uncontrolled hypertension, uncontrolled cardiac arrhythmias, symptomatic congestive heart failure, NYHA Class III or IV heart failure, unstable angina, clinically significant pericardial disease or myocardial infarction within the past 6 months, unless subject has a pacemaker. Prior to study entry, any ECG abnormality at Screening must be documented by the investigator as not medically relevant
Frontline therapy within 14 days or at investigator's discretion of the first dose of study drugs
Systemic treatment, within 14 days before or at investigator's discretion of the first dose of study drugs, with strong CYP3A inducers (rifampin, rifapentine, rifabutin, carbamazepine, phenytoin, phenobarbital), or use of St. John's wort or Ginkgo biloba
Any serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol
Known allergy to any of the study medications, their analogues, or excipients in the various formulations of any agent
Diagnosed or treated for another malignancy within 2 years before study enrollment or previously diagnosed with another malignancy and have any evidence of residual disease
Patients with non-melanoma skin cancer or carcinoma in situ of any type are
not excluded if they have undergone complete resection
\. Participation in other clinical trials throughout the duration of this
trial
\. Patient has been diagnosed with
Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein (M protein) and skin changes (POEMS) syndrome3
Primary amyloidosis
Plasma cell leukemia
Severe hypercalcemia, i.e., serum calcium 12 mg/dL (3.0 mmol/L) corrected for albumin
Clear my responses

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