Hemodynamic and Respiratory Tolerance of Intermittent Hemodialysis in Critically Ill Patients

  • STATUS
    Recruiting
  • days left to enroll
    69
  • participants needed
    200
  • sponsor
    University Hospital, Toulouse
Updated on 26 January 2021
electrolytes
critical illness
renal injury
renal replacement
replacement therapy
intermittent hemodialysis
renal replacement therapy

Summary

Acute kidney injury (AKI) affects up to 30% of critically ill patients and is associated with increased rates of mortality. Up to 60% of patients with AKI will ultimately require renal replacement therapy (RRT). Intermittent hemodialysis (IHD) is one of the main methods of RRT worldwide. In IHD-bicar, dialysate is composed by electrolytes, including calcium, and bicarbonate. To avoid calcium carbonate precipitation, dialysate has to be supplemented with acids (citric acid, chloride acid or acetic acid). However, IHD-bicar may be associated with hemodynamic instability or respiratory intolerance, mainly related to the CO2 release in the circulation during IHD (HCO3- <--> CO2 + H2O). Some recent studies showed that acetate free biofiltration (AFB-K), a technique that does not require dialysate acidification, could be associated with better hemodynamic stability and to a lower amount of CO2 delivered to the patients. AFB-K may thus improve the hemodynamic and respiratory tolerance of intermittent RRT in critically ill patients.

Description

In this prospective observational study, investigators aim to characterize the hemodynamic and respiratory tolerances of HDI-bicar and AFB-K in critically ill patients requiring RRT.

Details
Condition Renal Failure, Acute renal failure, Kidney Failure (Pediatric), Kidney Failure, acute kidney injury, acute kidney injuries
Treatment Collection of clinical and biological data during renal replacement therapy sessions
Clinical Study IdentifierNCT04444765
SponsorUniversity Hospital, Toulouse
Last Modified on26 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients 18 years old
Invasive monitoring of blood pressure
Non opposition to the research
Admission to the intensive care unit
Need of intermittent hemodialysis

Exclusion Criteria

Sodium bicarbonate infusion
Pregnancy or breastfeeding
Juridical protection
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