Study Of Intrabucally Administered Electromagnetic Fields and Regorafenib

  • STATUS
    Not Recruiting
  • days left to enroll
    66
  • participants needed
    25
  • sponsor
    Wake Forest University Health Sciences
Updated on 18 August 2023
cancer
systemic therapy
measurable disease
liver disease
cirrhosis
metastasis
TACE
radiofrequency ablation
sorafenib
ethanol injection
percutaneous ethanol injection
local therapy
hepatic arterial infusion
lenvatinib
arterial embolization
atezolizumab
regorafenib

Summary

The primary goal of this study is to gather efficacy data concerning the progression-free survival rate with electromagnetic fields plus Regorafenib when compared to historical data with Regorafenib alone as a second-line therapy in patients with advanced hepatocellular carcinoma who have received any first line systemic therapy either standard of care Sorafenib or Lenvatinib or any experimental therapy. Patients who have received any treatment that includes either electromagnetic fields or Regorafenib will be excluded.

Description

Primary Objective: To estimate progression-free survival rates.

Secondary Objectives

  • To obtain information concerning the feasibility of administration of the proposed treatment, including patient participation in trials using the proposed treatment.
  • To evaluate safety and tolerability in this patient population.
  • To evaluate the effect on levels of alpha-fetoprotein.

Details
Condition Hepatocellular Carcinoma
Treatment Regorafenib, TheraBionic
Clinical Study IdentifierNCT04327700
SponsorWake Forest University Health Sciences
Last Modified on18 August 2023

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