Cascade Genetic Testing of Familial Hypercholesterolemia (CATCH)

  • STATUS
    Recruiting
  • End date
    Dec 3, 2024
  • participants needed
    400
  • sponsor
    Center for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
Updated on 3 June 2022
cardiovascular disease
myocardial infarction
genetic disorder
genetic analysis

Summary

Familial hypercholesterolemia (FH) is a frequent genetic disorder (1/200) associated with an increased risk of early-onset myocardial infarction. To improve detection and treatment of patient with FH, cascade genetic testing in families is recommended by many cardiovascular prevention guidelines. However, the implementation of national genetic cascade screening is challenging, because legal protection to guarantee privacy of data do not authorize physicians to directly contact at-risk relatives. Using current mobile information technologies and a centralized web-based platform, we designed an ethical genetic cascade screening program for FH to be tested in Switzerland.

Details
Condition Familial Hypercholesterolemia
Treatment web-based centralized service and message
Clinical Study IdentifierNCT04419090
SponsorCenter for Primary Care and Public Health (Unisante), University of Lausanne, Switzerland
Last Modified on3 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

patients with severe hypercholesterolemia and familial or personal history of early-onset cardiovascular disease = Dutch Lipid Clinic Network score (DLNC) >= 6 points

Exclusion Criteria

Patients without at least one contactable first-degree family members
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