Lanadelumab in Bradykinin Angioedema
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- STATUS
- Recruiting
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- End date
- Sep 26, 2025
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- participants needed
- 80
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- sponsor
- University Hospital, Grenoble
Summary
A multicenter observational study aiming to evaluate the efficacy of kallikrein inhibition by lanadelumab in patients with bradykinin- angioedema
Description
The bradykinin-angioedema (AE-BK) is characterized by recurrent and unpredictable episodes of swelling; it can be disabling and disfiguring and the attacks affecting the larynx can be life-threatening.
The clinical symptoms depend on accumulation of bradykinin (BK), a vasoactive peptide responsible for vasodilation and increase of vascular leakage. BK formation depends on activation of the kallikrein-kinin cascade leading to uncontrolled generation of plasma kallikrein and subsequent proteolysis of high molecular-weight kininogen (HK).
Lanadelumab is a fully human monoclonal antibody inhibitor of plasma kallikrein, thereby preventing BK production; it represents an attractive therapeutic strategy for BK-AE prophylaxis.
The aim of this study is to evaluate the kallikrein inhibition by assessing the levels of cleaved HK and the immunogenicity of the lanadelumab.
Details
| Condition | Angioneurotic Edema, Urticaria, Vascular Diseases, Hives (Urticaria), angioedema, quincke's edema |
|---|---|
| Clinical Study Identifier | NCT04597944 |
| Sponsor | University Hospital, Grenoble |
| Last Modified on | 26 January 2021 |
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