Isolation Procedure vs. Conventional Procedure During Distal Pancreatectosplenectomy for Pancreatic Cancer

  • End date
    Sep 30, 2025
  • participants needed
  • sponsor
    Wakayama Medical University
Updated on 26 January 2021


In the distal pancreatectomy (including pancreatic tail resection) for invasive ductal carcinoma of the pancreas, we evaluate the usefulness of a procedure of firstly transection of splenic arteries and veins (the isolation procedure group) compared to a conventional procedure of transection of the splenic vein at the end.

Condition Resectable Pancreatic Body/Tail Carcinoma, Resectable Pancreatic Body/Tail Carcinoma, Resectable Pancreatic Body/Tail Carcinoma
Treatment Isolation procedure (RAMPS procedure), Conventional procedure
Clinical Study IdentifierNCT04600063
SponsorWakayama Medical University
Last Modified on26 January 2021


Yes No Not Sure

Inclusion Criteria

Resectable pancreatic cancer (Adenocarcinoma, adenosquamous cell carcinoma, mucinous carcinoma, and anaplastic carcinoma according to the 7th edition of the regulations for handling pancreatic cancer)
ASA-PS (American Society of Anesthesiology, General condition classification) is Class 1-3
Age are over 20 years old
Able to understand the content of the research and has obtained written consent from the person himself/herself

Exclusion Criteria

Non-resectable pancreatic cancer by image diagnosis at the initial diagnosis
Cases suspected of portal vein (superior mesenteric vein) invasion
Patients with severe ischemic heart disease
Patients with cirrhosis or active hepatitis requiring treatment
Patients with dyspnea requiring oxygen administration
Patients undergoing dialysis due to chronic renal failure
Cases in which arterial reconstruction of the superior mesenteric artery, common hepatic artery, celiac artery, etc. is considered necessary
Patients with strong suspected paraaortic lymph node metastasis
Active double cancer thought to affect adverse events and prognosis
Long-term oral steroids that may affect adverse events
Patients who are considered to have difficulty participating in the study due to psychosis or psychiatric symptoms
Cases other than invasive pancreatic ductal carcinoma by preoperative biopsy. Invasive intraductal papillary mucinous carcinoma (IPMC) is excluded
Patients who cannot use both iodine drugs and gadnium drugs due to severe drug allergy
Cases where the prescribed procedure is difficult due to history of upper abdominal surgery such as stomach, spleen, kidney, liver, transverse colon, retroperitoneum including pancreas and pancreatitis
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