Anesthesia and Acute Kidney Injury After Nephrectomy

  • End date
    Dec 25, 2022
  • participants needed
  • sponsor
    Seoul National University Hospital
Updated on 25 January 2021


This study investigates the influence of type of anesthesia on postoperative renal dysfunction in patients undergoing nephrectomy. The participants will be allocated to either the group receiving the total intravenous anesthesia (TIVA) using propofol or the group receiving the inhaled anesthetics using desflurane.


Nephrectomy is considered as a standard therapy for renal cell carcinoma, but it can cause postoperative renal dysfunction, such as acute kidney injury and chronic kidney disease. Therefore, it is imperative to identify modifiable risk factors for postoperative acute kidney injury after nephrectomy in advance. According to a recent retrospective study, total intravenous anesthesia using propofol is significantly associated with lower incidence of acute kidney injury after nephrectomy, compared to the inhalation anesthesia. However, there is no prospective study which investigates the influence of type of anesthesia on postoperative renal function after nephrectomy. Therefore, in the present study, we aimed to investigate the influence of type of anesthesia on acute kidney injury after nephrectomy by performing randomized controlled study.

Condition Nephrectomy, total nephrectomy
Treatment Propofol, Desflurane
Clinical Study IdentifierNCT04474600
SponsorSeoul National University Hospital
Last Modified on25 January 2021


Yes No Not Sure

Inclusion Criteria

Adults patients scheduled for elective open nephrectomy

Exclusion Criteria

Patients diagnosed with acute kidney injury preoperatively
Patients who have chronic kidney disease over stage 5 (estimated glomerular filtration rate [eGFR] <15 ml/kg/1.73m2) or have regular hemodialysis preoperatively
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