A Phase 1b Study of ADG116, ADG116 Combined With Anti-PD-1 Antibody or Anti-CD137 Antibody in Solid Tumors Patients
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- STATUS
- Recruiting
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- End date
- Dec 22, 2023
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- participants needed
- 204
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- sponsor
- Adagene Inc
Summary
This is a Phase 1, open-label, dose escalation study in patients with advanced/metastatic solid tumors. Study drug, ADG116, is an anti -CTLA-4 fully human monoclonal antibody that specifically binds to human CTLA-4. ADG106, a fully human ligand-blocking agonistic anti-CD137 IgG4 mAb, is expected to enhance the activity of activated T cells. The enhanced antitumor efficacy results observed from the preclinical studies of ADG116 in combination with ADG106 or anti-PD-1 provided further support to explore such combinations in clinical settings for better patient responses.
Details
| Condition | Advanced/Metastatic Solid Tumors |
|---|---|
| Treatment | ADG106, ADG116, anti PD1 drug |
| Clinical Study Identifier | NCT04501276 |
| Sponsor | Adagene Inc |
| Last Modified on | 22 March 2022 |
Eligibility
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