A Phase 1b Study of ADG116, ADG116 Combined With Anti-PD-1 Antibody or Anti-CD137 Antibody in Solid Tumors Patients

  • End date
    Dec 22, 2023
  • participants needed
  • sponsor
    Adagene Inc
Updated on 22 March 2022


This is a Phase 1, open-label, dose escalation study in patients with advanced/metastatic solid tumors. Study drug, ADG116, is an anti -CTLA-4 fully human monoclonal antibody that specifically binds to human CTLA-4. ADG106, a fully human ligand-blocking agonistic anti-CD137 IgG4 mAb, is expected to enhance the activity of activated T cells. The enhanced antitumor efficacy results observed from the preclinical studies of ADG116 in combination with ADG106 or anti-PD-1 provided further support to explore such combinations in clinical settings for better patient responses.

Condition Advanced/Metastatic Solid Tumors
Treatment ADG106, ADG116, anti PD1 drug
Clinical Study IdentifierNCT04501276
SponsorAdagene Inc
Last Modified on22 March 2022


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