Preventative Skin Care for Children Undergoing Targeted CNS Tumor Therapy

  • End date
    Dec 31, 2021
  • participants needed
  • sponsor
    Dana-Farber Cancer Institute
Updated on 26 January 2021
cancer treatment
brain tumor
mek inhibitor
braf inhibitor
cns tumor
skin care


This research study is examining a preventive skin care regimen for children diagnosed with a brain tumor and receiving anti-cancer therapy with a MEK, Pan-RAF, or BRAF inhibitor.


This prospective, single-arm phase 2 clinical trial is looking at whether gentle skin care, sun protection and dilute bleach baths might decrease the chances or the severity of skin changes that occur during treatment for brain tumors.

The research study procedures include screening for eligibility and study treatment including evaluations and follow up visits.

Participants will receive a study treatment regimen that involves a daily sun protection, daily gentle skin care and every-other-day dilute bleach baths for the duration of the study.

Participants enrolled in this study, will be in this research study during the course of their anti-cancer treatment and receive skin examinations and complete a survey about their skin condition at the initial visit when anti-cancer treatment is started, at six weeks after the start of anti-cancer treatment, and at twelve weeks after the start of anti-cancer treatment.

Participants will be followed for twelve weeks.

It is expected that about 20 people will take part in this research study.

Condition Dermatitis, Hand Dermatitis, Pediatric Cancer, Childhood Cancer, CNS Tumor, Childhood, CNS Tumor, Childhood, CNS Tumor, Childhood, inflammatory dermatosis, inflammation of the skin, skin inflammation, inflammation of skin, CNS Tumor, Childhood
Treatment Moisturizer, Warm Baths or Showers, SPF 30 or Higher Suncreen, Sun Protective Clothing, Limited Sun Exposure, Dilute bleach baths
Clinical Study IdentifierNCT04479514
SponsorDana-Farber Cancer Institute
Last Modified on26 January 2021


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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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