Ammonia Metabolism Assessed by Ammonia Infusion

  • End date
    Dec 31, 2022
  • participants needed
  • sponsor
    Aarhus University Hospital
Updated on 26 January 2021


The present study will develop a method to assess ammonia metabolism by ammonia infusion and investigate ammonia production and clearance in healthy individuals and in patients with liver cirrhosis.

Condition End Stage Liver Disease, Ammonia; Metabolic Disorder, Ammonia; Metabolic Disorder, Ammonia; Metabolic Disorder, Ammonia; Metabolic Disorder
Treatment Ammonia infusion
Clinical Study IdentifierNCT04585672
SponsorAarhus University Hospital
Last Modified on26 January 2021


Yes No Not Sure

Inclusion Criteria

Alcohol < 40g/day
BMI < 30
Diseased or medicated
Inclusion Criteria - Patients with cirrhosis
Child-Pugh A or B cirrhosis
BMI < 30

Exclusion Criteria

Child-Pugh score C
Kidney failure (eGFR < 60 mL/min/1.73m2)
Overt hepatic encephalopathy or more than one previous 1 episode of overt hepatic encephalopathy
Acute bacterial infection
Ammonia-targeted treatment of hepatic encephalopathy other than lactulose (including Rifaximin and branched-chain amino acids)
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note