Variability in Transcranial Doppler Technique in Neuro-Critical Care Patients

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    Hackensack Meridian Health
Updated on 17 November 2021


This study aims to determine the inter- and intra-variability of Transcranial Doppler (TCD) ultrasound in neuro-critical care patients who are planned for consecutive daily TCD evaluations.


Patients enrolled in the study are recruited from the pool of neuro-critical care patients admitted to the surgical intensive care unit (SICU). When the patients are admitted in the surgical ICU, the study staff will determine eligibility based on the protocol inclusion criteria. Due to the nature of the disease, there is a high likelihood that patients are either unconscious, of limited mental capacity and/or have been intubated therefore when appropriate the legally authorized representative will be utilized to obtain research consent.

To meet study inclusion, transcranial Doppler (TCD) testing will be ordered as part of the standard of care for these patients. The test will not be ordered solely for research purposes. There are no known side effects from the non-invasive measurement of cerebral blood flow using ultrasound

Three different TCD technicians will do triplicate readings on 3 consecutive days on up to 12 patients already undergoing TCD as ordered by their treating team. Standard of care on specific neuro critical care patients (such as cerebral aneurysms) is to undergo daily TCD monitoring to assess for possible vasospasm. Patients will be in the supine position while measurements are obtained. The probe will be placed in the preauricular region of the temporal window

Condition Cerebrovascular accident, Cerebral Infarction, Cerebral Ischemia, Berry Aneurysm, Subarachnoid Hemorrhage, Cerebrovascular Spasm, Aneurysm, Stroke, cerebral aneurysm, cerebral aneurysms, cerebral vasospasm, cerebral ischaemia, aneurysmal subarachnoid hemorrhage, cerebrovascular accidents, strokes, cerebral
Treatment transcranial Doppler
Clinical Study IdentifierNCT04583163
SponsorHackensack Meridian Health
Last Modified on17 November 2021


Yes No Not Sure

Inclusion Criteria

Adults 18 years of age or older
Current hospitalization for a neurologic issue and admitted to the surgical intensive care unit
Undergoing daily transcranial Doppler imaging No
English speaking patients and/or legally authorized representative (LAR)

Exclusion Criteria

Less than 18 years of age
Patient is unable to obtain consent and no LAR is identified to provide consent
Non-English speaking patient or LAR
Unable to perform the study due to lack of availability of TCD technologists
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