Analysis of Primary and Metastatic Tumors in Patients With Renal Cell Carcinoma and Urothelial Carcinoma

  • STATUS
    Recruiting
  • participants needed
    16
  • sponsor
    Fox Chase Cancer Center
Updated on 30 January 2023
carcinoma
metastasis
immune checkpoint inhibitor
transitional cell carcinoma
metastasectomy

Summary

This is a comparative study using resected/ biopsied tumors samples collected from renal cell carcinoma and urothelial carcinoma patients who underwent surgical removal of lesions, followed by immune checkpoint blockade (ICB) treatment targting programmed cell death 1 (PD1) but developed new lesions later were also removed and stored in the biosample repository (BSR). The histology and genomic analysis of the pre-treatment and metastatic samples from the same patient would be used to find out the changes that may have lead to metastasis. Also, metastatic samples from ICB naive patients would be collected and compared with those from ICB treated patients to find out if the metastasis in treated patients was due to development of reistance.

Details
Condition Renal Cell Carcinoma, Urothelial Carcinoma, Bladder Cancer, Ureter Cancer, Urethral Cancer
Treatment Immune checkpoint inhibitor targeting PD1
Clinical Study IdentifierNCT03291028
SponsorFox Chase Cancer Center
Last Modified on30 January 2023

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