Neuroinflammation in Hypertension Study

  • STATUS
    Recruiting
  • End date
    Feb 1, 2023
  • participants needed
    60
  • sponsor
    Royal Perth Hospital
Updated on 27 March 2021

Summary

To demonstrate that in patients with resistant hypertension oral treatment with minocycline via inhibition of central immune cell activation and inflammation results in reduced central sympathetic outflow and concomitant lowering of BP.

Description

This is a randomized, double-blind, placebo controlled, parallel group design study aiming to compare the effects of minocycline 100mg twice daily vs matched placebo for 12 weeks on ambulatory BP and the parameters of sympathetic and immune activation

Details
Condition Resistant Hypertension
Treatment Minocycline
Clinical Study IdentifierNCT04478500
SponsorRoyal Perth Hospital
Last Modified on27 March 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Aged: 45 -65 years
Signed informed consent
Clinical diagnosis of Resistant Hypertension
Daytime systolic ambulatory BP >135mmHg

Exclusion Criteria

eGFR of <45 mL/min/1.73m2
History of myocardial infarction (MI) or any cardiovascular event within 3 months of screening period, clinically significant AV conduction disturbances and/or arrhythmias
current of past history of heart failure (LVEF 40%)
psychotropic agents, antidepressants and NSAIDS
alcohol consumption of >3 standard drinks
known hypersensitivity or contraindication to minocycline or other tetracyclines
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