Neuroinflammation in Hypertension Study

  • End date
    Feb 1, 2023
  • participants needed
  • sponsor
    Royal Perth Hospital
Updated on 5 October 2021


To demonstrate that in patients with resistant hypertension oral treatment with minocycline via inhibition of central immune cell activation and inflammation results in reduced central sympathetic outflow and concomitant lowering of BP.


This is a randomized, double-blind, placebo controlled, parallel group design study aiming to compare the effects of minocycline 100mg twice daily vs matched placebo for 12 weeks on ambulatory BP and the parameters of sympathetic and immune activation

Condition Resistant Hypertension
Treatment Minocycline
Clinical Study IdentifierNCT04478500
SponsorRoyal Perth Hospital
Last Modified on5 October 2021


Yes No Not Sure

Inclusion Criteria

Aged: 45 -65 years
Signed informed consent
Clinical diagnosis of Resistant Hypertension
Daytime systolic ambulatory BP >135mmHg

Exclusion Criteria

eGFR of <45 mL/min/1.73m2
History of myocardial infarction (MI) or any cardiovascular event within 3 months of screening period, clinically significant AV conduction disturbances and/or arrhythmias
current of past history of heart failure (LVEF 40%)
psychotropic agents, antidepressants and NSAIDS
alcohol consumption of >3 standard drinks
known hypersensitivity or contraindication to minocycline or other tetracyclines
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note