Efficacy of Human Coronavirus-immune Convalescent Plasma for the Treatment of COVID-19 Disease in Hospitalized Children

  • STATUS
    Recruiting
  • End date
    May 1, 2022
  • participants needed
    100
  • sponsor
    The Hospital for Sick Children
Updated on 28 April 2021
covid-19
SARS
coronavirus infection

Summary

This is a multicentered, open-label, randomized controlled Phase 2 trial to evaluate the safety and efficacy of providing human coronavirus-immune convalescent plasma as treatment for COVID-19 disease in hospitalized children in the context of the COVID-19 pandemic.

Description

SARS-CoV-2 viral infection resulting in COVID-19 disease has recently been designated by the World Health Organization as a global pandemic. Outbreak forecasting and mathematical models suggest that the number of COVID-19 cases will continue to rise over the coming weeks and months. There is an urgent public health need for rapid development of novel interventions. This protocol aims to use passive antibody therapy via convalescent plasma from SARS-CoV-2-infected patients who have developed antibody immunity, COVID-19 convalescent plasma (C19-CP), as treatment for hospitalized children with COVID-19 disease at pediatric academic hospitals across Canada. The unknown role for convalescent plasma in treating COVID-19 necessitates further study.

Details
Condition hospitalized child, Covid-19 Infection, Covid-19 Infection, Covid 19 Infection
Treatment Convalescent Plasma (CP)
Clinical Study IdentifierNCT04377568
SponsorThe Hospital for Sick Children
Last Modified on28 April 2021

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