Effects of RT234 on Exercise Parameters Accessed by CPET in Subjects With PAH

  • End date
    Jul 3, 2022
  • participants needed
  • sponsor
    Respira Therapeutics, Inc.
Updated on 3 July 2021
pulmonary function test
connective tissue disease
forced expiratory volume
calcium channel blockers
exercise test
overlap syndrome
right heart catheterization
left ventricular end-diastolic pressure


The objectives of this study are to evaluate the effects of RT234 on exercise parameters assessed by a specialized exercise test (Cardiopulmonary Exercise Test or CPET) in patients with pulmonary arterial hypertension (PAH).


Consequences of pulmonary arterial hypertension are significant limitations in cardiorespiratory fitness (CRF), exercise capacity, as well as profound dyspnea with physical exertion. The objective of the present study is to assess the ability of a single inhaled dose of RT234 to acutely improve primary CPET measures of CRF and exercise capacity, and to lower the sensation of dyspnea with physical exertion compared to baseline CPET measures.

Condition Pulmonary Arterial Hypertension
Treatment Drug: RT234 - vardenafil inhalation powder; Device: Axially Oscillating Sphere dry powder inhaler (AOS DPI)
Clinical Study IdentifierNCT04266197
SponsorRespira Therapeutics, Inc.
Last Modified on3 July 2021


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