Effects of RT234 on Exercise Parameters Accessed by CPET in Subjects With PAH

  • STATUS
    Recruiting
  • End date
    Jul 3, 2022
  • participants needed
    40
  • sponsor
    Respira Therapeutics, Inc.
Updated on 3 July 2021
hypertension
immunodeficiency
pulmonary function test
vasodilator
connective tissue disease
cpet
forced expiratory volume
scleroderma
calcium channel blockers
digoxin
exercise test
overlap syndrome
right heart catheterization
left ventricular end-diastolic pressure
epoprostenol

Summary

The objectives of this study are to evaluate the effects of RT234 on exercise parameters assessed by a specialized exercise test (Cardiopulmonary Exercise Test or CPET) in patients with pulmonary arterial hypertension (PAH).

Description

Consequences of pulmonary arterial hypertension are significant limitations in cardiorespiratory fitness (CRF), exercise capacity, as well as profound dyspnea with physical exertion. The objective of the present study is to assess the ability of a single inhaled dose of RT234 to acutely improve primary CPET measures of CRF and exercise capacity, and to lower the sensation of dyspnea with physical exertion compared to baseline CPET measures.

Details
Condition Pulmonary Arterial Hypertension
Treatment Drug: RT234 - vardenafil inhalation powder; Device: Axially Oscillating Sphere dry powder inhaler (AOS DPI)
Clinical Study IdentifierNCT04266197
SponsorRespira Therapeutics, Inc.
Last Modified on3 July 2021

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