Treatment of Chronic Pelvic Pain Due to Endometriosis by Transcutaneous Auricular Vagus Nerve Stimulation

  • STATUS
    Recruiting
  • End date
    Feb 22, 2025
  • participants needed
    72
  • sponsor
    Hopital Foch
Updated on 22 December 2021
depression
dysmenorrhea
pelvic pain
endometriosis
dyspareunia
endometriosis surgery

Summary

6-10% of women of childbearing age suffer from endometriosis, which is mainly manifested by dysmenorrhea, non-menstrual pelvic pain and dyspareunia. Several treatment strategies, including surgical ones, are proposed but they are sometimes insufficient because endometriosis-related pain is frequently accompanied by sensitization. Endometriosis surgery, when indicated, is therefore changeably effective, even though the lesions have been completely resected. Patients therefore consult Pain Units seeking for the effective treatment as the pain persist even after surgical management of endometriosis.

Vagus nerve stimulation is a non-invasive technique that includes an anti-inflammatory effect and a modulation of neurotransmitter production (adrenaline, norepinephrine; serotonin, acetylcholine). Yuan and Silberstein published a general review on the technique. Migraine and depression are one of the selected indications. In addition, Napadow et al. published favourable results in a short series of patients with chronic pelvic pain. The Investigators of this study have treated some patients with this technique with a result deemed satisfactory which leads to propose a randomized study to confirm this impression.

Details
Condition Endometriosis
Treatment Transcutaneous Auricular Vagus Nerve Stimulation
Clinical Study IdentifierNCT04177511
SponsorHopital Foch
Last Modified on22 December 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Women aged >= 15 years
With chronic pelvic pain and/ or dysmenorrhoea and/ or dyspareunia
Who has been cared for by a gynecologist in one of the institutions participating in the study
Diagnosed with endometriosis
Having signed an informed written consent
Affiliated to a health insurance scheme

Exclusion Criteria

contraindication to the use of transcutaneous auricular vagus nerve stimulation (cardiac pathology, asthmatic patient)
pregnant or breastfeeding women
patient undergoing in vitro fertilization
associated pathology requiring long-term analgesic treatment
patient with atria trans vagal neurostimulation in the 12 months prior to inclusion
patient deprived of liberty or under guardianship
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