Efficacy and Safety of Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients With Established COVID-19

  • End date
    Sep 30, 2021
  • participants needed
  • sponsor
    Rabin Medical Center
Updated on 25 March 2021
diabetes mellitus
type 2 diabetes mellitus
pulmonary disease
type 1 diabetes mellitus
angiotensin converting enzyme
coronavirus infection
dipeptidyl peptidase-4 inhibitor
linagliptin 5 mg


The coronavirus disease 2019 (COVID-19) is an emerging pandemic in 2020 caused by a novel coronavirus named SARS-CoV2. Diabetes confers a significant additional risk for COVID-19 patients. Dipeptidyl peptidase 4 (DPP-4) is a transmembrane glycoprotein expressed ubiquitously in many tissues. In addition to its effect on glucose levels, DPP-4 has various effects on the immune system and several diseases, including lung diseases. This trial aims to assess the safety and efficacy of linagliptin, a DPP-4 inhibitor, in the treatment of COVID-19. The trial will be randomized without blinding, with one are treated by insulin only for glucose balance and the other by insulin and linagliptin. The trial will assess the effects of linagliptin on different measures of COVID-19 recovery.

Condition Endocrine disorder, Coronavirus Infection, Metabolic disorder, Incretins, NIDDM, Diabetes Mellitus, Dipeptidyl-Peptidase IV Inhibitors, Respiratory Tract Diseases, antidiabetic agent, Glucose Metabolism Disorders, Hormone, Coronavirus, Diabetes Mellitus, Type 2, Diabetes Prevention, Diabetes Mellitus Types I and II, Diabetes (Pediatric), Metabolic Disorders, Diabetes Mellitus Type 2, *COVID-19, Covid-19, Severe Acute Respiratory Syndrome Coronavirus 2, Linagliptin, Sars-CoV2, Sars-CoV2, type 2 diabetes mellitus, hormone agent, incretin, incretin hormone, hypoglycaemic agent, hypoglycaemic, antihyperglycemic, hypoglycemic agents, hypoglycemic drugs, hypoglycemic, hypoglycemic agent, diabetes mellitus (dm), metabolic diseases, metabolic disease, metabolism disorders, respiratory tract disease, type 2 diabetes, type ii diabetes, noninsulin-dependent diabetes mellitus, diabetes type 2, endocrinopathy, endocrine disorders, endocrine disease, endocrine diseases, SARS COV2
Treatment Linagliptin 5 MG
Clinical Study IdentifierNCT04371978
SponsorRabin Medical Center
Last Modified on25 March 2021


Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have any of these conditions: Diabetes Mellitus Types I and II or Endocrine disorder or NIDDM or Metabolic Disorders or Linagliptin or Metabolic disorder or Incretins or Severe Acu...?
Do you have any of these conditions: endocrine disease or hypoglycaemic or endocrine diseases or type ii diabetes or Metabolic Disorders or Diabetes Mellitus Type 2 or Severe Acute Respir...?
Do you have any of these conditions: Hormone or hypoglycemic agents or Linagliptin or incretin or antidiabetic agent or hypoglycemic or incretin hormone or Metabolic Disorders or Diabetes...?
Do you have any of these conditions: metabolic diseases or Metabolic Disorders or Diabetes Mellitus, Type 2 or incretin or Glucose Metabolism Disorders or Severe Acute Respiratory Syndrom...?
Age 18 years
History of or type 2 diabetes mellitus or a diagnosis of type 2 diabetes during hospitalization
Confirmation of infection with SARS-CoV-2 by PCR testing
Patients within 10 days from symptom onset or patients within 48 hours after laboratory diagnosis (SARS-CoV-2 PCR)

Exclusion Criteria

WHO COVID-19 Ordinal Scale for Clinical Improvement 6
Respiratory failure requiring mechanical ventilation prior to randomization
Use of vasopressor or inotropic medications prior to randomization
Intolerance/hypersensitivity to dipeptidyl peptidase-4 inhibitors
Patients expected to require intensive care unit admission or immediate surgical intervention
Participation in another trial assessing any treatment for COVID-19
Current treatment with a DPP-4 inhibitor
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