TCR +/CD19+ Depleted Allogeneic Hematopoietic Stem Cell Transplantation for Malignant and Non-malignant Disorders
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- STATUS
- Recruiting
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- End date
- Sep 26, 2025
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- participants needed
- 80
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- sponsor
- Children's Hospital Medical Center, Cincinnati
Summary
The purpose of this study is to investigate the safety and efficacy of TCR+/CD19+ depleted allogeneic hematopoietic stem cell transplant (HSCT) for malignant and non-malignant disorders in children and adolescent/young adult patients using the CliniMACS immunomagnetic selection device (Miltenyi Biotec).
Description
Acute graft versus host disease (GVHD) remains a significant cause of morbidity and mortality and is the biggest barrier to successful allogeneic hematopoietic cell transplantation (HSCT) outcomes. Improved methods of acute GVHD prevention are needed. TCR+/CD19+ depletion of allogeneic hematopoietic stem cell products offers an opportunity to limit the risk of acute GVHD by removing TCR+ T cells and CD19+ B cells which participate in acute GVHD initiation and perpetuation. The purpose of this study is to investigate the safety and efficacy of TCR+/CD19+ depleted allogeneic hematopoietic stem cell transplant (HSCT) for malignant and non-malignant disorders in children and adolescent/young adult patients using the CliniMACS immunomagnetic selection device (Miltenyi Biotec).
Details
| Condition | Allogeneic Hematopoietic Stem Cell Transplantation, Allogeneic Hematopoietic Cell Transplantation |
|---|---|
| Treatment | TCRαβ+/CD19+ depleted allogeneic hematopoietic stem cell transplant (HSCT) |
| Clinical Study Identifier | NCT04088760 |
| Sponsor | Children's Hospital Medical Center, Cincinnati |
| Last Modified on | 26 January 2021 |
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