FAPI-PET for Tumor Detection

  • End date
    Apr 30, 2027
  • participants needed
  • sponsor
    University Hospital, Essen
Updated on 25 May 2022
primary cancer
pet/ct scan


This is a prospective observational trial investigating correlation with histopathology, positive predictive value, detection rate, reproducibility and impact on clinical management of 68-Ga-FAPI PET/CT or PET/MRI in patients receiving this imaging modality for tumor staging or restaging as part of clinical care.


68-Ga-fibroblast-activation-protein-inhibitors (68-Ga-FAPI) are novel Positron emission tomography (PET) tracers that were recently introduced for the imaging of patients with various cancer diseases. The fibroblast-activation-protein (FAP) is highly expressed in carcinoma-associated fibroblasts (CAFs) in the stroma of various tumor entities. The aim of this registry study is to collect data on FAPI expression, positive predictive value, detection rate, reproducibility and impact on clinical management of 68-Ga-FAPI PET/CT or PET/MRI on patients receiving this imaging modality at initial diagnosis or restaging as part of clinical care.

Condition Malignant Neoplasm
Clinical Study IdentifierNCT04571086
SponsorUniversity Hospital, Essen
Last Modified on25 May 2022


Yes No Not Sure

Inclusion Criteria

FAPI-PET scheduled for staging or restaging as part of clinical routine for proven or suspected malignancy
Age ≥ 18 years

Exclusion Criteria

Patient cannot give consent for the study
Patient can not lie flat or tolerate FAPI PET imaging
Unwillingness or inability to comply with study and follow-up procedures
Condition of patient which is critical to participate in this study in the discretion of the investigators
Pregnant, lactating, or breast feeding women
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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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