Impact of a Patient-Centered Program for Low Anterior Resection Syndrome A Multicenter Randomized Controlled Trial

  • End date
    Dec 19, 2023
  • participants needed
  • sponsor
    Jewish General Hospital
Updated on 4 October 2022
rectal carcinoma
low anterior resection


After undergoing restorative proctectomy for rectal cancer, many patients are left with significant bowel dysfunction, known as Low Anterior Resection Syndrome (LARS). Increased LARS severity correlates with worse perceived global health status and quality of life (QoL). Among patients undergoing rectal resection with a permanent ostomy, there is evidence that supportive and educational interventions improve QoL, ostomy proficiency, self-efficacy and knowledge. However, evidence regarding the impact of such interventions in patients who undergo restorative proctectomy is lacking, despite the latter operation being far more frequently performed.

The overall goal of this study is to evaluate the extent to which a LARS Patient-Centered Program impacts on patient-reported outcome measures (PROMs) after restorative proctectomy for rectal cancer.

This is a randomized-controlled muticenter trial that will include patients who have undergone restorative proctectomy for neoplastic disease (benign or malignant) located in the rectum (0-15cm from the anal verge) with a diverting ostomy and who are scheduled for ostomy closure.

Condition Rectal Cancer, Surgery, Patient Activation, Low Anterior Resection, Low Anterior Resection Syndrome
Treatment Patient Activation Booklet and nursing support for patients with LARS
Clinical Study IdentifierNCT03828318
SponsorJewish General Hospital
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

Adult patients (>=18 years-old) who have undergone restorative proctectomy for neoplastic disease (benign or malignant) located in the rectum (0-15cm from the anal verge) with a diverting ostomy and who are scheduled for ostomy closure

Exclusion Criteria

Patients from whom clear and informed consent cannot be obtained
Patients unable to read and comprehend English or French
Patients who cannot be contacted by telephone
Patients who have undergone major colonic resection in addition to their proctectomy
Patients on active chemotherapy or radiotherapy treatment
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