Desmopressin for Bedwetting in Children With SCD

  • End date
    Dec 19, 2025
  • participants needed
  • sponsor
    Montefiore Medical Center
Updated on 19 June 2022
hemoglobin s
nocturnal enuresis


This study assesses if using the medication desmopressin will decrease nightime bedwetting in children with sickle cell disease.


Night time bedwetting is a common complication of sickle cell disease, and affects up to 30 % of children . Desmopressin is an oral medication that increases water reabsorption in the kidneys. Studies have shown that it is effective in decreasing bedwetting episodes in children without sickle cell disease. Chronic sickling episodes causing damage to the kidneys could cause permanent damage and may make this treatment ineffective in sickle cell disease. This trial will inform pediatric sickle cell doctors if desmopressin is an appropriate treatment for bed wetting in the investigators patients.

This is an edited continuation of study ID: 2014-3768.

Condition Nocturnal Enuresis, Anemia, Sickle Cell
Treatment Desmopressin
Clinical Study IdentifierNCT04420585
SponsorMontefiore Medical Center
Last Modified on19 June 2022


Yes No Not Sure

Inclusion Criteria

Patients with Hemoglobin SS, SC, SB0thal or SB+thal
Patients with at least two episodes of primary nocturnal enuresis per week or four episodes over the two weeks prior to enrollment
Patients with secondary enuresis who have been evaluated and cleared by a pediatric urologist as not having other etiologies of enuresis (e.g. overactive detrusor activity, a genitourinary anatomic abnormality)

Exclusion Criteria

Patients with developmental delay or neurologic dysfunction secondary to stroke
Patients with hypertension or underlying renal disease
Patients with genitourinary anatomic abnormalities. Any prior renal ultrasound showing normal genitourinary anatomy is sufficient to clear a patient for the study
Patients with daytime urinary incontinence
Patients with glucosuria on urinalysis
Patients with secondary nocturnal enuresis who have not been evaluated by a pediatric urologist to rule out other etiologies of enuresis
Patients who are pregnant
Patients receiving another medicine for nocturnal enuresis (e.g. imipramine)
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