Benefit of Systematic Proposition of Nicotine Substitution for Patients Undergoing Surgery

  • STATUS
    Recruiting
  • days left to enroll
    79
  • participants needed
    120
  • sponsor
    Groupe Hospitalier Mutualiste de Grenoble
Updated on 7 August 2021
diabetes
COPD
carbon monoxide
addiction
pulmonary disease
asthma
nicotine replacement

Summary

Smoking is associated with a higher rate of surgical complications. For example, in orthopedics, the risk of complications is 31% in smokers against 5% in non-smokers. The management of this addiction is recommended and particularly interesting in scheduled surgery, because it allows smoking cessation well before the procedure. However, for patients who cannot consider this smoking cessation, the mere information of the risk cannot be sufficient and a real strategy must be constructed and evaluated.

Currently, studies results indicate that a patient reducing the number of smoked cigarettes will unconsciously modify their smoking behaviour to obtain the usual nicotine level, this effect is called self-titration. Conversely, nicotine replacement while continuing consumption could induce an improvement in smoking behaviour, therefore less intoxication which would be beneficial in terms of reduction of post-operative complications. This study seeks to assess the effectiveness of a systematic proposition of nicotine replacement therapy (NRT) in regular smokers. Tobacco addiction specialists have demonstrated that intoxication and dependence are well correlated with the exhaled carbon monoxide (CO) level, so this measurement will be used in addition to the patient's interview.

Details
Condition Smoking Cessation, smoking cessation therapy
Treatment NRT proposition and exhaled CO measurement
Clinical Study IdentifierNCT04572646
SponsorGroupe Hospitalier Mutualiste de Grenoble
Last Modified on7 August 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patient who smokes at least one cigarette or cannabis joint per day, every day
Patient received for nurse consultation at least 48 hours before surgery
Patient planned to undergo surgery, with entry the day of surgery and 1 day of post-operative hospitalisation
Patient in physical capacity and willing to undergo exhaled carbon monoxide measurement
For patients with one of the following chronic diseases: diabetes, Chronic Obstructive Pulmonary Disease, glucose intolerance, hemolytic anemia, asthma and dilation of the bronchi, these diseases must be stable
Signature of the specific study informed consent
Patient affiliated or beneficiary of social security system

Exclusion Criteria

Inability to submit to study follow-up for geographic, social or psychological reasons
Patient already included in an interventional clinical research protocol
Patients protected by French law from clinical research inclusion (pregnant, in labour, breastfeeding, legally protected, under judiciary or administrative liberty deprivation)
Patient using nicotine substitutes before the nurse consultation
Alcohol consumption six hours before the exhaled carbon monoxide measurement
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