The Crosstalk Between Calcium-sensing Receptor Signaling and Endocannabinoid System in Primary Hyperparathyroidism

  • STATUS
    Recruiting
  • End date
    Jul 31, 2022
  • participants needed
    90
  • sponsor
    University Hospital Inselspital, Berne
Updated on 17 October 2021
calcium
cytokines
prostaglandin
endocannabinoid
primary hyperparathyroidism

Summary

Despite the strong association of hyperparathyroidism with arachidonic acid related lipid signals, little research has been performed over the years. A better understanding of the link between arachidonic acid remodeling, prostaglandin and endocannabinoid production with primary hyperparathyroidism in primary tissue/cells might open up new avenues for biomarker and thus to a potential therapeutic target.

Arachidonic acid remodeling might also have an impact on depression and elevated cytokines in patients with primary hyperparathyroidism. The investigators therefore will assess the correlation between postoperative improvement of PHQ-9 and cytokine levels with arachidonic acid remodeling.

Details
Condition Hyperparathyroidism, Primary hyperparathyroidism, Hyperparathyroidism (Pediatric)
Clinical Study IdentifierNCT03831620
SponsorUniversity Hospital Inselspital, Berne
Last Modified on17 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 18 years
Primary hyperparathyroidism with planned surgery
Written informed consent

Exclusion Criteria

Age <18 years
Secondary/tertiary hyperparathyroidism
Renal insufficiency
Participant is pregnant
Participant is incapable of giving an informed consent
Clear my responses

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