Objective Measurements of the Opacification of the Lens After Vitrectomy

  • STATUS
    Recruiting
  • End date
    Oct 26, 2023
  • participants needed
    100
  • sponsor
    Fondation Ophtalmologique Adolphe de Rothschild
Updated on 26 January 2021
bilateral cataracts
retinal detachment

Summary

Cataract is the opacification of the lens. Usually cataract occurs slowly, causing progressive vision loss over several months or years.

In ophthalmic clinical practice, repeated objective quantitative measurements of lens opacity may be necessary to document its progression and support a surgical indication.

The subjective methods of evaluating the opacification of the lens have limitations, in particular due to the lack of reproducibility between observers. Thus, innovative objective techniques with precise and reproducible cataract classification results have been developed, such as the Objective Scatter Index (OSI) on the Optical Quality Analysis System (OQAS), Visiometrics SL in 2010 and, more recently, Average Lens Density (ALD) on the IOLMaster 700 device. Cataract is diagnosed as mature when the OSI is 2 and / or when the ALD is 74 pixel units.

Vitrectomy is a surgery of the posterior segment of the eye indicated for retinal detachment, epimacular membranes, macular holes, vitreous hemorrhage. The incidence of post-vitrectomy cataract varies among studies, and the methodology is often retrospective. Age has already been identified as a risk factor for progression since in a study of 28 eyes of patients under 50 years old, only 7% developed cataracts secondarily, compared to 79% in the 'over 50' group.

To date, there is no prospective study describing the progression kinetics of lens opacification according to precise and reproducible quantitative objective criteria in patients treated by vitrectomy. It also involves confirming the age and preoperative lens status as a risk factor for postoperative cataract progression.

Details
Condition Cataract, Vitrectomy, Cataracts
Treatment Objective Scatter Index (OSI), Average Lens Density (ALD)
Clinical Study IdentifierNCT04566237
SponsorFondation Ophtalmologique Adolphe de Rothschild
Last Modified on26 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have any of these conditions: Cataract or Cataracts or Vitrectomy?
Do you have any of these conditions: Vitrectomy or Cataract or Cataracts?
Patient over 18 years old
Indication for unilateral 3-way vitrectomy for retinal detachment, macular hole, epiretinal membrane, vitreous hemorrhage
Bilateral phakic patient

Exclusion Criteria

Vitrectomy combined with cataract surgery
Pregnant or breastfeeding woman
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