Effect of Anthracyclines and Cyclophosphamide on Cardiovascular Responses

  • End date
    Nov 3, 2022
  • participants needed
  • sponsor
    University of Sao Paulo General Hospital
Updated on 10 October 2021
adjuvant chemotherapy


The present study aims to investigate the chronic effect of treatment with doxorubicin and cyclophosphamide on neurovascular control and blood pressure in women undergoing adjuvant treatment for breast cancer.


The development of new drugs and different adjuvant therapeutic regimens, based on the combination of anthracycline (A) and cyclophosphamide (C), have contributed greatly to improve survival rate in breast cancer patients. Despite the clinical benefits of this therapy, AC treatment can cause cardiovascular acute and chronic changes. In a recent investigation, we observed that an acute AC chemotherapy session increases sympathetic nervous activity and blood pressure in patients with breast cancer.

The present study aims to investigate the chronic effects of AC regimen on sympathetic nervous activity, peripheral vasoconstriction, endothelial microparticles and blood pressure, in women with breast cancer.

Condition Breast Cancer, Cardiovascular Disease, Diet and Nutrition, Chronic Diarrhea, Skin Wounds, Chronic Shoulder Pain, Vaginal Atrophy, Adverse Effects, Drugs, Injection Port, Breast Cancer - HER2 Positive, Anal Dysplasia, Primary Immunodeficiency, Pediatric Health, Near-Sighted Corrective Surgery, Cardiotoxicity, Peripheral Arterial Occlusive Disease, Breast Cancer Diagnosis, Brain Function, Cardiac Toxicity, Recurrent Respiratory Papillomatosis, Razor Bumps (Pseudofolliculitis Barbae), Metastatic Triple-Negative Breast Cancer, Neurovascular Disorder, Endothelial Disfunction, breast carcinoma, cancer, breast, cardiovascular diseases, cardiovascular disease (cvd), cardiovascular system diseases, cardiovascular disorders
Treatment Blood pressure, Heart Rate, Physical Characteristics, Muscular Sympathetic Nervous Activity, Cardiac Function, Cardiac Function, Blood Assessments, Muscle blood flow, Endothelium-dependent vascular function, Vascular intima-media thickness, Physical Capacity, Physical Capacity, Anthracycline & Cyclophosphamide treatment scheme
Clinical Study IdentifierNCT04568161
SponsorUniversity of Sao Paulo General Hospital
Last Modified on10 October 2021


Yes No Not Sure

Inclusion Criteria

diagnosis of stage II-III breast cancer
starting adjuvant chemotherapy

Exclusion Criteria

metastatic disease
hypercholesterolemia, diabetes
severe lymphedema
organic disorders (renal failure, heart failure and chronic liver disease)
obesity (BMI> 30) and
who are under pharmacological treatment with statins, angiotensin-converting enzyme inhibitors, losartan potassium, beta blockers or antioxidants
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