Measuring Taste Perception During Chemotherapy for Muscle Invasive Bladder Cancer

  • End date
    Dec 23, 2023
  • participants needed
  • sponsor
    University of Kansas Medical Center
Updated on 23 March 2022
radical cystectomy
invasive bladder cancer
bladder tumor


Alteration in the sense of taste is a frequent symptom that is closely linked to chemotherapy exposure, lowering quality of life and nutritional status. Malnutrition is of particular concern in muscle-invasive bladder cancer (MIBC), as malnutrition is associated with many negative outcomes from radical cystectomy (the surgical procedure in MIBC), which include higher morbidity, poor wound healing, and higher rate of infections after surgery.

It is essential to understand taste changes among participants receiving chemotherapy for MIBC to create future treatment trials.

Condition Bladder Cancer
Clinical Study IdentifierNCT04567719
SponsorUniversity of Kansas Medical Center
Last Modified on23 March 2022


Yes No Not Sure

Inclusion Criteria

Ability of participant OR Legally Authorized Representative (LAR) to understand this study, and participant or LAR willingness to sign a written informed consent
Age ≥ 18 years
Histologically proven MIBC (Muscle Invasive Bladder Cancer) without metastatic disease Diagnosis
Planning to undergo neoadjuvant chemotherapy and radical cystectomy for MIBC

Exclusion Criteria

No prior systemic chemotherapy for MIBC
Cannot be simultaneously enrolled in any therapeutic clinical trial, unless receiving standard neoadjuvant chemotherapy on said clinical trial
Any oral or cognitive pathology impairing the ability to perform taste testing procedures
No other known malignancy within previous 2 years with the following EXCEPTIONS: Low-grade prostate cancer on active surveillance, CLL on surveillance / observation, non-melanoma skin cancers
No psychiatric illness/social situations that would limit compliance with study requirements
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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