Salivary Flow Rate Response to Electrostimulation in HD Patients

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  • participants needed
  • sponsor
    Cairo University
Updated on 26 January 2021


Xerostomia is a subjective complaint of dry mouth, whereas hyposalivation is an objective decreased of salivary flow. Hyposalivation was reported in 28.8 % of haemodialysis (HD) patients (Bruzda-Zwiech, 2014).


Stimulation of the salivary glands can be induced mechanically (for example, by chewing gum or acupressure) or through medications (such as pilocarpine, cevimeline, angiotensin-converting-enzyme inhibitors and angiotensin-receptor blockers) or by electrostimulation as transcutnaeous electrical nerve stimulation (TENS) (Bossola and Tazza, 2012).

Eighty HD patients (40 diabetics and 40 nondiabetics) will receive 20 minutes of TENS on skin over bilateral parotid gland, 3 times weekly for 3 weeks to investigate the hyposalivation response of diabetic and non diabetic HD patients to TENS.

Condition Hemodialysis Complication
Treatment TENS
Clinical Study IdentifierNCT04562519
SponsorCairo University
Last Modified on26 January 2021


Yes No Not Sure

Inclusion Criteria

Is your age between 30 yrs and 80 yrs?
Gender: Male or Female
Do you have Hemodialysis Complication?
Do you have any of these conditions: Do you have Hemodialysis Complication??
Do you have any of these conditions: Do you have Hemodialysis Complication??
Eighty HD patients (40 diabetics and 40 non diabetics)
HD at least from three month
saliva flow less than or equal 0.15 millilitre per minute

Exclusion Criteria

pulmonary or cardiac disorders
drugs to treat hyposalivation
salivary glands inflammation, tumor, and autoimmune diseases
smokers and alcholics
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