Different Anesthetic Strategies on Postoperative Cognitive Function and Delirium in Patients Undergoing Cardiac Surgery

  • End date
    Jan 18, 2023
  • participants needed
  • sponsor
    China National Center for Cardiovascular Diseases
Updated on 7 March 2022
heart surgery
coronary artery bypass graft
cardiac operation


This is a prospective, multi-center, double-blind, randomized clinical trials.


Prospective randomized multi-center trial involving about 502 subjects will be enrolled in 3 centers. Patients will be randomized to two groups in equal proportion. Investigators set a hypothesis that precision cardiac anesthesia, which involves the modification of several crucial anesthetic modalities, would reduces the incidence of postoperative cognitive function and delirium in patients undergoing cardiac surgery.

Condition Delirium, Condition, Anesthesia
Treatment Precision cardiac anesthesia, Conventional cardiac anesthesia
Clinical Study IdentifierNCT04505059
SponsorChina National Center for Cardiovascular Diseases
Last Modified on7 March 2022


Yes No Not Sure

Inclusion Criteria

Aged≥18 years
Hemodynamic stability, LVEF≥40%
Cardiac surgery including CABG, valve surgery, CABG combined with valve surgery, surgical repair of ASD,VSD and atrial myxoma, and other types

Exclusion Criteria

Declined to get involved
Emergency cases, heart transplantation
Severe hepatic insufficiency (Child-Pugh grades C),Severe renal insufficiency (requirement of renal replacement therapy)
Previous history of drug and alcohol abuse,allergy to general anesthetics
Preoperative severe dementia, language barrier and mental illness
Preoperative schizophrenia, epilepsy, stroke and Parkinson's disease
Previous history of craniocerebral injury or neurosurgery
Any other conditions that are considered unsuitable for study participation
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