Extinction Learning in Adults With Tourette Syndrome

  • End date
    Sep 30, 2023
  • participants needed
  • sponsor
    Johns Hopkins University
Updated on 7 October 2022
behavior therapy
tourette's syndrome
vocal tic
Accepts healthy volunteers


Aversive sensory phenomena such as premonitory urges play a central role in the behavioral treatment model of tics. Extinction learning and extinction recall are learning processes implicated within this model, but are still understudied for individuals with Tourette syndrome (TS). This study examines extinction learning and extinction recall in adults with TS using an experimental task. This study will also explore the relationship between extinction processes (i.e., extinction learning and extinction recall) and treatment outcomes with behavior therapy. Findings from this investigation will be used to update the behavioral treatment model, which serves as the basis for evidence-based behavioral interventions.

Condition Tourette Syndrome, Habit Reversal Training, Tic Disorders, Tics, Comprehensive Behavioral Intervention for Tics
Treatment Habit Reversal Training
Clinical Study IdentifierNCT04498364
SponsorJohns Hopkins University
Last Modified on7 October 2022


Yes No Not Sure

Inclusion Criteria

At least 18 years old
Have moderate tic severity or greater as evidenced by a YGTSS Total Tic Score greater than 13 (>9 for youth with motor or vocal tics only)
Have not received more than 4 previous sessions of HRT
Be fluent in English
Medication free or on a stable dose of psychiatric medication for 8 weeks prior to enrollment

Exclusion Criteria

An inability to complete rating scales
An inability to attend study visits
Clear my responses

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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