Thrombus Aspiration in STEMI Patients With High Thrombus Burden

  • STATUS
    Recruiting
  • End date
    Feb 29, 2024
  • participants needed
    3838
  • sponsor
    Guangdong Provincial People's Hospital
Updated on 16 March 2021
clot
stemi
percutaneous coronary intervention

Summary

This is a prospective, multicenter, open-label, randomized, controlled, parallel group study, in which ST-segment Elevation Myocardial Infarction (STEMI) patients with high thrombus burden(TIMI thrombus grade 3) are included. Patients are randomized to be treated with or without manual thrombus aspiration(TA) during primary percutaneous coronary intervention(PPCI) by a ratio of 1:1.

Description

This study is intended to explore the efficacy of thrombus aspiration (TA) in ST-Segment Elevation Myocardial Infarction (STEMI) patients with high thrombus burden who received primary PCI within 12 hours after the onset of symptoms, reducing the incidence of cardiovascular death, recurrent myocardial infarction, stent thrombosis, target vessel revascularization within 180 days or stroke in 30 days.

Details
Condition Myocardial Infarction, Heart Attack (Myocardial Infarction), Heart Attack (Myocardial Infarction), STEMI, ST Segment Elevation Myocardial Infarction
Treatment thrombus aspiration
Clinical Study IdentifierNCT04212494
SponsorGuangdong Provincial People's Hospital
Last Modified on16 March 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 18 years
STEMI patients undergoing primary PCI within 12 hours after the onset of symptoms
High thrombus burden after guidewire passes the lesion (TIMI thrombus grade 3)
Informed consent must be voluntary

Exclusion Criteria

Haemodynamic instability or cardiogenic shock
After thrombolytic therapy
The predicted survival time is less than 6 months due to non-cardiac disease
History of coronary artery bypass grafting
Participate in other researches within 30 days
Preoperative gastrointestinal bleeding or contraindications to dual antiplatelet therapy
Patients were considered unsuitable by other researchers
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