Retrospective study examining the differences in vocalizations of babies and toddlers with Rett compared to same age peers

Updated on 15 July 2022
Kate Worley
Primary Contact
The University of Tennessee Health Science Center (online study) Contact
Online studies
Accepts healthy volunteers


Retrospective study examining the differences in vocalizations of babies and toddlers with Rett compared to same age peers: We are looking to recruit children and their parent(s) to participate in a study examining the early speech development of infants and toddlers later diagnosed with Rett syndrome, compared to girls their age with no diagnosis of rett syndrome.  
You and your child's participation in this study will take no more than 2 sessions.  The first session will last around 1 hour, and the second session will last aroudn 1 hour.  Both sessions will be conducted by either telephone or video-chat (i.e. Zoom).
Parent(s) will be asked to share home video recordings (from a cellphone or camera) taken of their daughter between 6-18 months of age.  Parent(s) will also be asked to answer interview quesitons regarding their daughter's early development.


The purpose of this study is to observe the early sound development and social communication of infants and toddlers diagnosed with Rett syndrome compared to girls of their same age without Rett syndrome. Thus far, limited research has been done on the early speech and language development of females diagnosed with Rett syndrome, prior to the regression of skills. Identifying potential differences in early vocal development of females later diagnosed with Rett syndrome could provide more information for earlier detection of this genetic disorder. 

Condition Rett Syndrome, congenital varietyRett syndrome, Cdkl5-related, Rett syndrome, preserved speech varietyRett syndrome, atypical
Clinical Study IdentifierTX253203
Last Modified on15 July 2022


Yes No Not Sure

Inclusion Criteria

Inclusionary: Females between the ages of 4-10, with or without a diagnosis of Rett syndrome. Participants must be able to provide video recordings of the participating child between 6 to 18 months of age

Exclusion Criteria

Children with a diagnosis of any other developmental disorders. Families who are not able to provide videos of the participating child between the ages of 6 to18 months. participate in the interview portion of the study (i.e., phone or computer they could use zoom on). For any child who is an age matched peer, they can not report any previous speech or language issues (i.e., late talker, speech sound impairments, language delay/disorder, hearing impairment). Females with a hearing loss or hearing impairment
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note