CLAD: Finding Biomarkers to Predict Rejection and/ or Outcome After Lung Transplantation

  • End date
    Oct 25, 2039
  • participants needed
  • sponsor
    University Hospital, Antwerp
Updated on 25 January 2021


Lung transplantation is the ultimate treatment for end stage lung diseases. Survival after lung transplantation is limited mainly due to the development of chronic allograft dysfunction (CLAD). Both acute cellular rejection and primary grade dysfunction (PGD) have been associated with the development of CLAD. In this study we will investigate multiple prognostic factors that influence long term survival after lung transplantation with a specific interest in PGD, acute rejection and the development of CLAD.


At specific time points (according to protocol) exhaled breath, blood specimens, bronchoalveolar lavage and biopsies will be collected. These will be analyzed in an attempt to identify possible biomarkers that will predict the development of PGD and/or CLAD.

Condition Primary Graft Dysfunction, Lung Transplant Failure and Rejection
Treatment blood and exhaled breath specimens
Clinical Study IdentifierNCT04558333
SponsorUniversity Hospital, Antwerp
Last Modified on25 January 2021


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Inclusion Criteria

all lung transplant recipients > 18 years signed ICF (informed consent form)

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