Effect of Polymorphisms in the IL-1 Gene Complex on the Development of Chronic Hepatitis and Hepatocellular Carcinoma

  • STATUS
    Recruiting
  • participants needed
    1600
  • sponsor
    National Taiwan University Hospital
Updated on 7 November 2020
hepatitis
hepatocellular carcinoma

Summary

The purpose of this study is to determine the effect of polymorphisms in the IL-1 gene complex on the development of chronic hepatitis and hepatocellular carcinoma.

Description

We analyzed single-nucleotide polymorphisms in the genes for interleukin-1a, interleukin-1b, interleukin-1-receptor antagonist, interleukin-1-receptor type I, and interleukin-1-receptor type II in 400 normal control and patients (chronic hepatitis and hepatocellular carcinoma). Genotypes were tested for an association with development of chronic hepatitis and hepatocellular carcinoma by multivariable analysis. A second cohort of 1200 normal control and patients (chronic hepatitis and hepatocellular carcinoma) was independently analyzed for the genotype associations identified in the first cohort.

Details
Condition Hepatitis B, Genetic Polymorphism, HEPATOCELLULAR CARCINOMA
Clinical Study IdentifierNCT00155103
SponsorNational Taiwan University Hospital
Last Modified on7 November 2020

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