Generalized Hypersensitivity in Patients With Fibromyalgia Syndrome

  • STATUS
    Recruiting
  • End date
    Jul 1, 2025
  • participants needed
    100
  • sponsor
    University of Florida
Updated on 24 November 2021
chronic pain
pain disorder
Accepts healthy volunteers

Summary

Fibromyalgia (FM) is a chronic musculoskeletal pain disorder with unknown causes. Our previous studies showed abnormal sensations of second pain (wind-up), indicating central hypersensitivity as an important mechanism of FM. Triggering events have been implicated as the cause of central hypersensitivity.

Description

Increasing evidence has shown that the hypersensitivity of FM is not limited to painful stimuli but seems to extend to non-painful stimuli as well. These stimuli include smell, taste, touch, light, and sound. This study will provide detailed QST examinations of FM subjects and controls' responses to light using visually evoked potentials (VEP). In addition, careful characterization of experimental pain responding across multiple sensory modalities will be examined.

Details
Condition Myofascial Pain Syndrome, fibro, Fibromyalgia
Treatment Paced Auditory Serial Addition task (PASAT)
Clinical Study IdentifierNCT04415866
SponsorUniversity of Florida
Last Modified on24 November 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Individuals diagnosed with FM will have pain of > 3 months and meet the 1990 and 2011 Diagnostic Criteria for FM (ACR)
Healthy, pain-free age and sex matched controls without chronic pain

Exclusion Criteria

Presence of chronic disease (e.g. cancer, cardiovascular disease, liver disease, kidney disease, diabetes, etc.)
FM patients must be willing to discontinue or hold their FM related medications for a minimum of one day prior to the visit
Significant vision loss not corrected by eye wear
Family history of photosensitive epilepsy
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