Enamel Matrix Derivative in Non-surgical Periodontal Treatment
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- STATUS
- Recruiting
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- End date
- Jan 23, 2023
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- participants needed
- 50
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- sponsor
- Medical University of Vienna
Summary
The aim of the study is to investigate the effect of enamel matrix derivative in addition to scaling and root planing in comparison to scaling and root planing only in periodontitis patients that have already undergone initial periodontal therapy and are in periodontal maintenance.
Description
Enamel matrix derivative (EMD) have already been widely applied as a regenerative bio-modulator in periodontal surgery and have been demonstrated to enhance periodontal regeneration. Recently, also its flapless, non-surgical application has been shown to have beneficial effects when applied during initial therapy of periodontitis.
The present study is designed as a single-blinded randomized controlled clinical trial. We plan to include a total of 50 periodontitis patients that have already undergone initial periodontal therapy, but still show remaining sites with increased periodontal probing depth (PPD). Patients will be randomly allocated at a 1:1 ratio to either scaling and root planing (SRP) in combination with EMD application into the affected pockets (test group, n=25) or to SRP only (control group, n=25). Before treatment, as well as after 3, 6 and 12 months, we plan to assess site-specific periodontal parameters as well as whole-mouth oral hygiene indices. Furthermore, we intend to evaluate gingival crevicular fluid, as well as parameters representing periodontal disease activity.
Details
| Condition | Periodontitis |
|---|---|
| Treatment | Scaling and root planing, Emdogain® FL |
| Clinical Study Identifier | NCT04449393 |
| Sponsor | Medical University of Vienna |
| Last Modified on | 23 April 2022 |
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