Study to Evaluate Blood and Urine Kidney Injury Markers to Facilitate Early Detection of Renal Adverse Drug Events in Pediatric Cancer Patients Treated With Nephrotoxic Chemotherapy

  • End date
    Aug 27, 2022
  • participants needed
  • sponsor
    University Hospital, Basel, Switzerland
Updated on 27 January 2021
renal function
blood test
renal injury
renal function test


This study is to investigate blood and urine kidney injury markers (especially Uromodulin) in pediatric cancer patients treated with nephrotoxic chemotherapy. Uromodulin is a marker to detect and monitor tubular injury and renal function.

Condition Renal Impairment, Renal Dysfunction, Impaired Renal Function, Kidney Impairment, kidney insufficiency
Treatment blood test for renal biomarkers, urine test for renal biomarkers
Clinical Study IdentifierNCT04308642
SponsorUniversity Hospital, Basel, Switzerland
Last Modified on27 January 2021


Yes No Not Sure

Inclusion Criteria

signed informed consent by their-selves ( 14 years) or their legal representatives (< 14 years or in case of lacking capacity of judgement)
cancer diagnosis, that indicates a nephrotoxic chemotherapy including the drugs High Dose MTX (HD-MTX), ifosfamide, cis- and carboplatin

Exclusion Criteria

critically-ill patients with inotropic and/or vasopressor drugs
signs of severe Sepsis
receiving other nephrotoxic drugs parallel to the chemotherapy cycle
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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