A Phase II Study to Determine Pembrolizumab as Frontline Treatment of Patients With Hodgkin Lymphoma

  • STATUS
    Recruiting
  • End date
    Jul 14, 2023
  • participants needed
    25
  • sponsor
    Peter MacCallum Cancer Centre, Australia
Updated on 14 December 2021
corticosteroids
lymphoma
measurable disease
chemotherapy regimen
bleomycin
dacarbazine
vinblastine
adriamycin

Summary

The purpose of this study is to test how safe and effective the research study drug, pembrolizumab is as a treatment for patients with Hodgkin lymphoma who have not previously been treated for this disease and are unsuitable for standard treatment (adriamycin, bleomycin, vinblastine, dacarbazine ABVD).

Description

The study is a single arm, open label, phase II, international, multi-centre study. Sample size will be 25 evaluable patients with a recruitment period of 2 years. Patients will be administered 200mg pembrolizumab IV every 3 weeks up to 35 cycles or 2 years. Patients will be followed-up for 1 year.

Details
Condition Hodgkin Lymphoma
Treatment Pembrolizumab
Clinical Study IdentifierNCT03331731
SponsorPeter MacCallum Cancer Centre, Australia
Last Modified on14 December 2021

Eligibility

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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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