Niraparib Maintenance in Patients With Advanced Ovarian Cancer at Neoadjuvant Setting

  • STATUS
    Recruiting
  • End date
    Oct 1, 2023
  • participants needed
    48
  • sponsor
    The University of Hong Kong
Updated on 6 October 2021
carcinoma
carboplatin
cancer chemotherapy
parp inhibitor
fallopian tube
platinum-based chemotherapy
niraparib
immunostimulant
primary peritoneal carcinoma
peritoneal carcinoma
tumor debulking
cytoreductive surgery
intraperitoneal chemotherapy
cancer of the ovary
interval debulking surgery

Summary

This study aims to evaluate the effects of niraparib in those who have received neoadjuvant chemotherapy and subsequent interval debulking surgery, with or without hyperthermic intraperitoneal chemotherapy, and would also explore if there are any biomarkers, other than BRCA / HRD status and platinum sensitivity, that may help to identify those who may benefit from PARPi especially those who are HRD negative.

Description

Despite cytoreductive surgery and platinum-based chemotherapy, about 70% of patients with advanced ovarian cancer recur in the first 2 - 3 years. PARPi has been shown to be prolong survival in primary advanced ovarian cancer. However its role in neoadjuvant setting has not been fully evaluated.

Details
Condition ovarian tumors, Ovarian Cancer, cancer of the ovary, Ovarian Function, Recurrent Ovarian Cancer, ovarian carcinomas, cancer, ovarian, Ovarian disorder, cancer ovarian
Treatment Niraparib
Clinical Study IdentifierNCT04284852
SponsorThe University of Hong Kong
Last Modified on6 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients must be at least 18 years old
Patients must have newly diagnosed, histologically confirmed high grade, serous or endometrioid, FIGO stage 3 or 4, ovarian, fallopian tube or primary peritoneal carcinoma before the start of NACT
Patients must have received 3 - 4 cycles of NACT containing either carboplatin or cisplatin, IDS with or without HIPEC, and 3 - 6 more cycles of adjuvant chemotherapy, prior to recruitment into the study
The patients should have only one cytoreductive surgery
The patients must show either complete (CR) or partial response (PR) to the platinum-based chemotherapy using RECIST 1.1 criteria
Patients should not be amenable to further surgery or radiotherapy except for the purpose of symptomatic relief
All surgery, chemotherapy and radiotherapy should finish more than 3 weeks prior to recruitment
Niraparib should be started within 8 weeks after the last dose of chemotherapy
Patients should have Eastern Cooperative Oncology Group (ECOG) performance score 0 to 2 within 28 days prior to recruitment
Patients must have adequate bone marrow, renal, hepatic and neurological function within 28 days prior to the start of treatment
Patients who have childbearing potential should practice highly effective contraception throughout the study until at least 30 days after completion of the treatment

Exclusion Criteria

Patients who are diagnosed to have low-grade or borderline carcinoma, mucinous or clear cell cystadenocarcinoma, carcinosarcoma or undifferentiated carcinoma, are excluded
Patients who have stable disease or PD on the post-treatment scan or clinical evidence are excluded
Patients who have drainage of ascites within 4 weeks before recruitment are excluded
Patients who have with concurrent malignancy within five years (except for basal or squamous cell skin cancer or in-situ breast cancer) are excluded
Patients who have history of unresolved thrombocytopenia, myelodysplastic syndrome or acute myeloid leukaemia are excluded
Patients who have symptomatic brain or leptomeningeal metastases, or spinal cord compression are excluded unless these are treated and controlled within 28 days of recruitment
Patients with the significant past medical history, such as active hepatitis, myocardiac infarction, in the last six months are excluded
Patients with severe gastrointestinal conditions such as evidence of bowel obstruction in the last 4 weeks prior to enrolment, or history of inflammatory bowel disease, are not eligible
Patients having had severe infections within 4 weeks prior to the start of treatment are excluded
Patents with active tuberculosis, history of positive test for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome (AIDS) are excluded
Patients with prior allogeneic stem cell or solid organ transplantation are excluded
Those patients who suffer from CTCAE grade 2 or more toxicity from previous treatment, except alopecia, are excluded
Patients who have used PARPi previously are excluded
Patients who are allergic to any component of niraparib are excluded
Patients who have used bevacizumab, or who are going to use bevacizumab as maintenance, are not eligible to join the study
Use of other investigational drugs within 28 days or at least 5 half-lives (whichever is longer) before study drug administration is not allowed
Patients who are pregnant or breastfeeding are excluded
Patients must not have either platelet or red blood cell transfusion, or granulocyte colony stimulating factor (G-CSF) within 2 weeks of the first dose of study treatment
Patients must not plan to donate blood during the study or for 90 days after the last dose of study treatment
Patients with major operation within 28 days or open biopsy within 7 days before enrolment are not eligible
Patients planned to have major surgery during the course of the study are excluded
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