Cognitive Stimulation for Elderly Bipolar Patients (TONIC)

  • participants needed
  • sponsor
    Groupe Hospitalier de la Rochelle Ré Aunis
Updated on 3 June 2023
cognitive impairment
neurodegenerative disorders
cognitive disorder
cognitive stimulation


Age is a major risk factor for the development of cognitive disorders and neurodegenerative pathologies. Cognitive disorders during the phases of bipolar disease are known to exist, and alterations increase significantly after the age of 65. Drug treatments seem to have only a limited effect. A cognitive stimulation program has proven his benefit to patients over 65 with neurodegenerative diseases (Israel, 2004). We propose to evaluate this cognitive stimulation program that we have adapted to bipolar disease.


Bipolar disorders, which belong to the category of mood disorders, are the 6th leading cause of disability in the world. Cognitive disorders are known to exist during the phases of bipolar disease, and alterations increase significantly after the age of 65. Recent studies have shown that attention, memory and executive function impairments are the main causes of cognitive disorders. Residual symptoms have a significant impact on the risk of relapse into bipolar disorder and on quality of life. Cognitive stimulation (CS) is a pedagogical approach based on the idea that cognitive skills contribute to personal development in the same way as psychological and social factors. This study aims at assessing a cognitive stimulation program initially developed for patients with neurodegenerative diseases, and adapted to bipolar disease. This program will be compared to the usual practice consisting in consultation with psychiatrist and sometimes in intervention of home nurses.

Condition Bipolar Disorder, Cognitive Impairment, Age-related Cognitive Decline
Treatment Cognitive Stimulation
Clinical Study IdentifierNCT04184375
SponsorGroupe Hospitalier de la Rochelle Ré Aunis
Last Modified on3 June 2023

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