Cabozantinib and Pembrolizumab for Advanced Metastatic Melanoma

  • STATUS
    Recruiting
  • End date
    Jul 1, 2024
  • participants needed
    39
  • sponsor
    Yousef Zakharia
Updated on 25 September 2021

Summary

The study aims to evaluate the safety and preliminary efficacy of the combination of cabozantinib and pembrolizumab in advanced melanoma

Description

This is an open-label, Phase 1b/2 trial for adults with advanced melanoma. The objective of the Phase 1b portion of the study is to establish the recommended Phase 2 dose of cabozantinib in combination with pembrolizumab in patients with unresectable melanoma and assess the safety and tolerability of the combined treatments. The objective of the Phase 2 portion of the study is to evaluate the preliminary efficacy of the established dose of cabozantinib in combination with pembrolizumab as measured by best overall response rate (ORR) (complete response [CR] + partial response [PR]) with the combination of agents in patients with unresectable stage III or stage IV melanoma.

Details
Condition Advanced Metastatic Melanoma
Treatment Pembrolizumab, Cabozantinib
Clinical Study IdentifierNCT03957551
SponsorYousef Zakharia
Last Modified on25 September 2021

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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