Cabozantinib and Pembrolizumab for Advanced Metastatic Melanoma
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- STATUS
- Recruiting
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- End date
- Jul 1, 2024
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- participants needed
- 39
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- sponsor
- Yousef Zakharia
Summary
The study aims to evaluate the safety and preliminary efficacy of the combination of cabozantinib and pembrolizumab in advanced melanoma
Description
This is an open-label, Phase 1b/2 trial for adults with advanced melanoma. The objective of the Phase 1b portion of the study is to establish the recommended Phase 2 dose of cabozantinib in combination with pembrolizumab in patients with unresectable melanoma and assess the safety and tolerability of the combined treatments. The objective of the Phase 2 portion of the study is to evaluate the preliminary efficacy of the established dose of cabozantinib in combination with pembrolizumab as measured by best overall response rate (ORR) (complete response [CR] + partial response [PR]) with the combination of agents in patients with unresectable stage III or stage IV melanoma.
Details
| Condition | Advanced Metastatic Melanoma |
|---|---|
| Treatment | Pembrolizumab, Cabozantinib |
| Clinical Study Identifier | NCT03957551 |
| Sponsor | Yousef Zakharia |
| Last Modified on | 4 October 2022 |
Eligibility
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