Brown Adipose Tissue Activation by Spinal Cord Stimulation

  • STATUS
    Recruiting
  • End date
    Oct 1, 2024
  • participants needed
    10
  • sponsor
    Oregon Health and Science University
Updated on 1 May 2022
diabetes
type 2 diabetes mellitus
spinal cord
failed back surgery syndrome
back surgery

Summary

The objective of this study is to investigate and utilize spinal cord stimulation (SCS) as an effective approach to eliciting weight loss and potentially alleviating Type 2 diabetes mellitus (DM), as evidenced by increasing metabolism of adipose tissue.

Description

This research study aims to investigate possible activation of brown adipose tissue (BAT) metabolism by upper thoracic spinal cord stimulation (SCS). We believe that our multidisciplinary research team presents a unique opportunity to test whether SCS can activate BAT metabolism, as tested during a routine screening procedure for spinal cord stimulation (SCS) for pain control. Our marker for BAT activation is 18F-fluorodeoxyglucose (FDG) - positron emission tomography (PET), which has previously been used to gauge cold-evoked BAT activation, and other studies of BAT in humans. We believe this proof-of-concept study could pave the way for a new therapeutic modality for the treatment of morbid obesity, and Type 2 Diabetes Mellitus.

Details
Condition Pain, Back, Obesity, Morbid, Type 2 Diabetes
Treatment Research electrode
Clinical Study IdentifierNCT04326192
SponsorOregon Health and Science University
Last Modified on1 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age: 21-70 years
Persistent neuropathic leg and back pain
Subjects who are already planning to undergo SCS for pain
Subjects who have not received a prior SCS trial for pain
Subjects with a BMI of 25-45, using formula; weight (lb) / [height (in)]2 x 703

Exclusion Criteria

Not considering SCS for pain
Forensic patient
Taking beta blockers
Weight change > 5% within last 3 months
Habitual tobacco use
Habitual excessive alcohol use
Pregnancy
Decisionally impaired adults
Children
Neonates
Subjects with a BMI of <25 or >45
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