Brown Adipose Tissue Activation by Spinal Cord Stimulation
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- STATUS
- Recruiting
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- End date
- Oct 1, 2024
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- participants needed
- 10
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- sponsor
- Oregon Health and Science University
Summary
The objective of this study is to investigate and utilize spinal cord stimulation (SCS) as an effective approach to eliciting weight loss and potentially alleviating Type 2 diabetes mellitus (DM), as evidenced by increasing metabolism of adipose tissue.
Description
This research study aims to investigate possible activation of brown adipose tissue (BAT) metabolism by upper thoracic spinal cord stimulation (SCS). We believe that our multidisciplinary research team presents a unique opportunity to test whether SCS can activate BAT metabolism, as tested during a routine screening procedure for spinal cord stimulation (SCS) for pain control. Our marker for BAT activation is 18F-fluorodeoxyglucose (FDG) - positron emission tomography (PET), which has previously been used to gauge cold-evoked BAT activation, and other studies of BAT in humans. We believe this proof-of-concept study could pave the way for a new therapeutic modality for the treatment of morbid obesity, and Type 2 Diabetes Mellitus.
Details
| Condition | Pain, Back, Obesity, Morbid, Type 2 Diabetes |
|---|---|
| Treatment | Research electrode |
| Clinical Study Identifier | NCT04326192 |
| Sponsor | Oregon Health and Science University |
| Last Modified on | 1 May 2022 |
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