Decitabine-primed Tandem CD19/CD20 CAR T Cells Plus Epigenetic Agents in Aggressive r/r B-NHL With Huge Tumor Burden

  • STATUS
    Recruiting
  • participants needed
    80
  • sponsor
    Chinese PLA General Hospital
Updated on 24 September 2022

Summary

This open-label, multi-cohorts, phase 1/2 study has the primary objective of comparing decitabine-primed tandem CART 19/20 solo, with decitabine-primed tandem CART 19/20 plus chidamide, decitabine-primed tandem CART 19/20 plus decitabine, and decitabine-primed tandem CART 19/20 plus decitabine+chidamide in patients with aggressive B-NHL who were confirmed as Relapsed and/or Refractory B cell Non-Hodgkin's Lymphoma with hugh tumor burden (Sum of the Product of the perpendicular Diameters for multiple lesions, SPD 100cm^2 or the largest-diameter of tumor 10 cm.).

Details
Condition Refractory or Relapsed Non-Hodgkin's Lymphoma, Refractory or Relapsed Non-Hodgkin's Lymphoma, Refractory or Relapsed Aggressive r/r B-NHL With Huge Tumor Burden, Refractory or Relapsed Aggressive r/r B-NHL With Huge Tumor Burden, Refractory or Relapsed Aggressive r/r B-NHL With Huge Tumor Burden
Treatment Decitabine, Chidamide, Chidamide and Decitabine, Tandem CAR19/20 engineered T cells, Decitabine-primed Tandem CAR19/20 engineered T cells
Clinical Study IdentifierNCT04553393
SponsorChinese PLA General Hospital
Last Modified on24 September 2022

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