Cardiovascular Risk Reduction in Atrial Fibrillation Trial
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- STATUS
- Recruiting
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- End date
- Aug 25, 2025
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- participants needed
- 6000
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- sponsor
- Beijing Anzhen Hospital
Summary
Atrial fibrillation (AF) is a serious public health problem because of its increasing incidence and prevalence in the aging population. AF is associated with elevated risks of death, stroke, coronary event, heart failure, cognitive decline, and chronic kidney disease. To identify preventive interventions for major cardiovascular events beyond effective anticoagulation should be a major priority in the treatment of AF patients. The CRAFT study is a 2-arm, multicenter, randomized clinical trial designed to test whether intensive blood pressure control will reduce the risk of major cardiovascular events in AF patients.
Description
The CRAFT trial will include approximately 6000 AF patients with home SBP 125-154 mmHg and at least another cardiovascular risk factor. The trial aims to compare the effects of randomization to a treatment program of an intensive SBP goal (target home SBP <120mmHg) with randomization to a treatment program of a standard goal (target home SBP <135mmHg). The primary hypothesis is that cardiovascular event rates will be lower in the intensive arm. Participants will be recruited over a 3-year period at approximately 100 to 150 clinical centres and the first patient will be followed for up to 5 years.
Details
| Condition | arterial hypertension, High Blood Pressure (Hypertension), Arrhythmia, high blood pressure, Atrial Fibrillation (Pediatric), Dysrhythmia, Hypertension, Atrial Fibrillation, High Blood Pressure (Hypertension - Pediatric), Elevated Blood Pressure, Vascular Diseases, Diabetes and Hypertension |
|---|---|
| Treatment | Intensive BP control, Standard BP control |
| Clinical Study Identifier | NCT04347330 |
| Sponsor | Beijing Anzhen Hospital |
| Last Modified on | 25 June 2021 |
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