Impact of Long Alimentary Limb or Long Biliary Limb Roux-en-Y Gastric Bypass on Type 2 Diabetes Remission in Severely Obese Patients.

  • STATUS
    Recruiting
  • End date
    Jun 25, 2024
  • participants needed
    396
  • sponsor
    University Hospital, Lille
Updated on 25 January 2021

Summary

In patients with type 2 diabetes, Roux-en-Y gastric bypass (RYGB), which excludes a portion of the stomach and the proximal intestine from the alimentary circuit, improves glucose metabolism more rapidly and more extensively than is expected from weight loss. The mechanisms of this unique effect of gastrointestinal exclusion appear to be complex and have not yet been clarified. A recent study unveil that intestinal uptake of ingested glucose is diminished by RYGB and restricted to the common limb, where food meets bile and other digestive fluids, resulting in an overall decrease of post prandial blood glucose excursion. the hypothesize that reducing the length of the common limb, which is rarely measured and highly variable in clinical practice, may significantly affect the metabolic outcome of gastrointestinal surgical procedures. The aim of the present study is to compare the impact of two variants of Roux-en-Y gastric bypass with a short common limb, the long alimentary limb or the long biliary limb Roux-en-Y gastric bypass, on type 2 diabetes remission in severely obese patients.

Details
Condition Diabetes Mellitus Type 2 in Obese
Treatment Standard Roux-en-Y gastric bypass, Long alimentary limb Roux-en-Y gastric bypass
Clinical Study IdentifierNCT03821636
SponsorUniversity Hospital, Lille
Last Modified on25 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

BMI 35 kg/m2
All patient with type 2 diabetes
Patients who were candidates for obesity surgery in accordance with French recommendation

Exclusion Criteria

Severe cognitive or mental disorders
patient who have already undergone obesity surgery
Severe and non-stabilised eating disorders
The likely inability of the patient to participate in lifelong medical follow-up
Alcohol or psychoactive substances dependence
The absence of identified prior medical management of obesity
Diseases that are life-threatening in the short and medium term
Contraindications to general anaesthesia
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