COVID-19 Related Lung Ventilation and Perfusion Injury

  • days left to enroll
  • participants needed
  • sponsor
    McMaster University
Updated on 16 September 2021


Little is currently known about the immediate and long-term effect of COVID-19 on lung ventilation (delivery of air to the lungs) and lung perfusion (delivery of blood to the lungs). Some people who survive COVID-19 may have lung ventilation and/or perfusion injury that persists following COVID-19 recovery. This lung injury may be related to inflammation in the lung, breathlessness, exercise limitation and reduced quality of life. Therefore, towards the goal of understanding the effects of COVID-19 on lung health, the purpose of this study is to characterize and understand the clinical relevance of COVID-19 related lung ventilation and perfusion injury and associated inflammatory status, 4 weeks and 6-months following COVID-19 recovery in an asthmatic and healthy population. To do this, an asthmatic and healthy population who have, and have not, been previously diagnosed with COVID-19 will be studied.

Condition Asthma, healthy, Allergies & Asthma, Asthma (Pediatric), *COVID-19, Covid-19, asthmatic, bronchial asthma
Treatment spirometry, V/Q SPECT-CT, St. George's Respiratory Questionnaire (SGRQ), mMRC (Modified Medical Research Council) Dyspnea Scale, Six-minute walk test (6MWT), Plethysmography & DLCO, Airwave Oscillometry
Clinical Study IdentifierNCT04549636
SponsorMcMaster University
Last Modified on16 September 2021


Yes No Not Sure

Inclusion Criteria

For all participants
Males and females 18 years of age
Individuals able and willing to provide written informed consent
Individuals able and willing to comply with the study protocol
For participants with asthma
Individuals with physician confirmed asthma (12% bronchodilator reversibility or PC20 methacholine less than 8mg/ml)
Individuals treated with inhaled corticosteroids, oral corticosteroids and/or anti-T2 biologics
For participants who recently recovered from covid-19
Individuals previously diagnosed with covid-19 confirmed by FLOQswab test
Individuals who recently (4-weeks) recovered from covid-19

Exclusion Criteria

For all participants
Males and females < 18 years of age
Individuals who are unable to read and/or understand English
Individuals who are pregnant or breastfeeding
Individuals who currently smoke or are an ex-smoker with 10 pack-year smoking history
Individuals who in the opinion of the investigator, are mentally or legally incapacitated, preventing informed consent from being obtained
Individuals who are unable to complete one or more study manoeuvres
For participants with no history of lung disease
Individuals with a history of respiratory infection or disease
For participants who have not been diagnosed with covid-19
Individuals who have previously had covid-19 confirmed by FLOQswab test
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