Uterine Scratching in Intra-Uterine Insemination

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    Clinique Ovo
Updated on 7 October 2022
unexplained infertility
Accepts healthy volunteers


This study will evaluate the potential benefits of uterine injury during the follicular phase of an intra-uterine insemination cycle on the rate of ongoing pregnancy during the first trimester ultrasound.


Infertility is defined as the absence of conception after a year of unprotected intercourse. In 10 to 30 % of patients, the cause of the infertility is unknown. An emerging practice in unexplained infertility has been to cause a uterine trauma prior to treatment. This is done by doing a small endometrial scratch with a pipelle. This intervention has been study in IVF and has been shown beneficial. Theoretically, the uterine scratching could increase the immune response and the vascularization of the endometrium which could help in embryo implantation. However, there is very few data concerning scratching in intrauterine insemination. The studies are mostly small studies and the results are often contradictory. In this randomized controlled trial, the investigators will evaluate the effect of uterine scratching during the follicular phase of an insemination cycle on the pregnancy rate of a large cohort of unexplained infertile couples.

Condition Infertility, Unexplained Infertility
Treatment Endometrial scratching
Clinical Study IdentifierNCT03828786
SponsorClinique Ovo
Last Modified on7 October 2022


Yes No Not Sure

Inclusion Criteria

Unexplained infertility for over 12 months if under 35 years old or over 6 months if 35 years old and above
At least one permeable tube on hysterosonography or hysterosalpingography within the last 2 years or vaginal delivery in the last 3 years
Antral follicular count over 5
Normal or mild male factor
Normal uterine cavity
An IUI prescription

Exclusion Criteria

Polycystic ovary syndrome with irregular menstrual cycles over 45 days
Severe endometriosis
IUI with Donor sperm
Patient with invasive intra-uterine procedure in the last 3 months
Contraindication to endometrial biopsy
Clear my responses

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